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Because the majority of diabetes patients have T2DM, prescribing practices and clinical guidelines consistently prioritize GLP-1 therapy for this group, ensuring that T2DM remains the leading indication driving revenue and market share within the global GLP-1 receptor agonist segment
The hypothesis driving its design was straightforward but unverified at the time: that engaging GIP and GLP-1 receptors simultaneously, pathways which are normally co-secreted from the gut following a meal, would produce additive or synergistic effects on insulin secretion, gastric motility, and downstream metabolic markers beyond what either pathway could deliver alone
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It seems to downregulate pro-inflammatory cytokines while promoting an environment conducive to healing
